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The accumulation of unpreferred synonymous substitutions along the D. melanogaster lineage was previously hypothesized to be due solely to relaxation of selective constraint maintaining codon bias (Akashi 1995, 1996; McVean and Vieira 2001).
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The last constraint maintains the minimum required rate of each D2D pair.
The smoothness constraint maintains the quality and the smoothness (i.e., similar RDC) between consecutively coded MBs.
The "physical world constraint" maintains the fundamental laws of the physical world, such as "rigid objects never overlap".
These movements are suggested to be facilitated by conformational changes of amino acids in the transmembrane domain that relieve structural constraints maintaining the inactive state.
The sequences showed a low nucleotide diversity, which suggests selective constraints maintaining this regulatory region over evolutionary time.
This silent divergence indicates that NASP evolution has been subject to strong functional constraints maintaining essential structural features required for the protein's proper functioning.
Rapid acceleration of respiratory CO2 production was observed in the buds following the transition from low to ambient temperatures, demonstrating alleviation of the constraints maintaining the quiescent state.
The fairly constant number of older paralogous families can be due to selective constraints maintaining the elevated copy number or if the loss of paralogs is dependent on sequence similarity, such that after ~10% sequence divergence, paralog loss is negligible.
Our results show that OBP genes are significantly clustered across the Drosophila evolution (P < 0.033), suggesting the existence of some functional constraints maintaining the clusters (Quijano et al. 2008).
These constraints maintain a dynamic lifespan for all tracked objects.
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