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We have made the assumption that i) the network formed by polymer chains trapped between different crystallites and ii) the changes in local density from crystalline regions to purely amorphous regions, may be both represented by an ad-hoc constraint exerted on the amorphous phase.
The polymers are designed such that after exactly 18 –CH2− units an azobenzene-moiety (bearing either an o,o-dihydrogen (H-azo) or an o,o-difluorinated azo-moiety (F-azo) is placed, able to photochemically switch cis/trans configuration, thus changing the geometrical constraint exerted on the alkyl-moiety during crystallization and its crystal packing.
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In the absence of DNA repair activity in the mature gamete, the integrity of the paternal genome is potentially challenged by the unique topological constraints exerted on sperm DNA [3].
We show that patterned constraints exerted on the tissue by the extracellular matrix are key to force the tissue into the right shape.
Gene duplications have been the subject of many functional and molecular studies in plants [ 24, 25], but here we aimed at analysing specifically the selective constraints exerted on duplicated genes through analysis of their rates of substitution.
Thus, after analysing the selective constraints exerted on the regulatory genes, we performed a systematic characterization of the cis- and trans-regulatory elements predicted in the Buchnera genomes from the five sequenced strains.
Part of this inconsistency between in vitro and in vivo mechanical load magnitude could occur due to the non-physiological conditions during cell culture, such as two dimensional culture conditions which lack the connections and constraints exerted on the bone architecture due to the presence of mineralized matrix.
The ModelBuilder object constructs the nodes and masses on the nodes, creates the elements and materials of the elements, defines the loads exerting on the nodes and the elements, and defines the constraints exerting on the nodes.
Based upon this Jacobian matrix, the constraint force exerted on the moving platform of the PKM can be found.
This suggests that some strong constraint is exerted on the evolution of these peculiar genes.
For envW, the corresponding ratio was 0.8 [ 19], precluding definite conclusions (yet, a subsequent study on envW identified a region of the gene with a lower ratio compatible with a functional constraint specifically exerted on that domain [ 26]).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com