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In this paper the dynamic interactions between an idealized rotating circular string and a stationary constraint, consisting of a spring, a damper, a mass or a frictional restraint, are discussed.
A tricyclic nisin mimic was designed and synthesized in which both thioether moieties were mimicked by an alkane-bridge, as well as the introduction of a third conformational constraint consisting of a macrocyclic lactam-bridge between the N-terminus and the B-ring.
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The elastic constraint consists of a transverse and rotational spring, as well as a tangential spring, which couples the extensional motion of one span with the other.
The delay constraint consists of a target delay and the probability of exceeding it,.
For this purpose, mechanical constraints, consisting of an appropriate homogenization model, are added as regularization factors to the optimization algorithm.
Additional constraints consisted of a rho- independent termination pattern situated 35 85 bp downstream the two basic 5' end patterns shown above.
The lung constraints consisted of a central lung distance below 3 cm, the mean lung dose had to be <7.5 Gy, the heart constraints consisted of a maximum heart distance below 1 cm, the heart volume receiving >10 Gy had to be <5 %, and the heart volume receiving >5 Gy had to be <10%%.
Final state constraint consists of the goal proposition that needs to hold at sequence index K.
To summarize, the design approach for the robust FSBB using the WCMP optimization with the PRV constraint consists of the following steps.
MVN minimize the same functional while interpolating a network of geometric constraints consisting of surface position, tangent plane, and surface curvatures.
MVC minimize the arc length integral of the square of the arc length derivative of curvature while interpolating a set of geometric constraints consisting of position, and optionally tangent direction and curvature.
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