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Pancreatic ductal adenocarcinoma shows a distinct apoptosis resistance, which contributes significantly to the aggressive nature of this tumor and constrains the effectiveness of new therapeutic strategies.
In previous work, we demonstrated that the intracellular stability of TS is increased by the binding of inhibitory ligands [ 7], a phenomenon that potentially constrains the effectiveness of TS-directed anti-cancer agents.
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This medical welfare reform definitely called for assistance from the healthcare system reform; in turn, the difficulty of promoting the latter inevitably constrained the effectiveness of the former.
High challenge stress consistently helped to strengthen the effectiveness of work-family balance practices in reducing work-family conflict, while high hindrance stress constrained the effectiveness of work-family practices on work-family conflict.
Fuel shortages, inadequate pilot training, and a lack of coordination between units also constrained the effectiveness of the fighter force.
However, the rearing of a single strain of actinomycetes could constrain the effectiveness of the ant-Pseudonocardia symbiosis, because multiple strains of antibiotic-producing bacteria within individual colonies would increase the diversity of compounds produced to defend against Escovopsis (Poulsen et al. in preparation).
The realisation that weak health systems constrained the effectiveness of many of their interventions increased attention for HSS.
However coordination challenges between military, civil society and NGOs can constrain the effectiveness of medical response [ 47].
Additionally, the quality of the waste heat, and thus its ability to do useful work, are important parameters that may constrain the effectiveness of this approach.
Furthermore, it became rapidly clear that weak health systems, for instance through health workforce deficits, severely constrained the effectiveness of many high impact interventions [ 2].
However, the study results also suggest that there exist several health systems barriers that constrained the effectiveness of the intervention in influencing the availability of data, analysis and response.
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