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Furthermore, as a consequence of their disruptive nature they preclude the collection of time-course data from a single adherent cell population, which in turn constrains the detection of short-term transient or dynamic cellular responses.
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Until recently, differentially expressed miRNAs were discovered using miRNA microarray technology, which is subject to certain limitations such as difficulties in detecting low abundance miRNAs and a limited dynamic range, essentially constraining the detection of subtle fold changes.
Semi-quantitative indices may constrain the detection of change in joints if synovial thickening greatly exceeds the largest score by delivering static scores when genuine reduction in synovial thickening can be detected quantitatively.
This severely constrains the detection and functional analysis of allelic variants, which play a key role in controlling many complex traits.
In the development of the algorithm we made a number of assumptions about the shape of the EPG, which were based on the known range of EPG parameters from prior manual analyses and helped constrain the detection problem.
Divergence in high-duty cycle echolocation may be selectively stronger since tuning of the constant frequency component and the auditory fovea for insect flutter detection constrains the use of acoustics for social purposes.
Conventional mammography is a screening procedure constrained by low specificity in the detection of breast cancer.
The experimental conditions used were chosen to mimic the natural environment of R. baltica; however, stress conditions were constrained by the detection limit of the microarray technology used and, hence, were required to elicit a sufficiently pronounced response from the organism.
Peer pressure constrains the expression of sexual desire.
This massively constrains the realm of possible outcomes.
What constrains the spread of a variant?
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