It has been demonstrated that nucleosomes constrain accessibility of enzymatic apparatus to certain regions of associated DNA [ 21].
54 On the other hand, another study suggested that secondary structures of the nonresponsive 3′ UTRs might constrain the accessibility to target sites.
On a playing field leveled by OA, users can selectively access, use and cite those articles that they judge to be of the highest relevance and quality, no longer constrained by their accessibility.
a) Difficulties in accessing primary healthcare services The reduced proximity to primary healthcare centres in certain rural areas was seen by the GPs as an important accessibility constrain.
Given the increasing availability of complete mt genomes from a range of taxa, marker choice is no longer constrained by the accessibility of universal primers [ 31].
While congestion can constrain mobility and reduce accessibility, traffic is also associated with agglomerations of activity and is thus a byproduct of proximity-based accessibility.
Usability of the screen readers is mainly constrained by the complex structure/poor accessibility of web pages.
The study found that although Flushing has rather convenient transportation and destination accessibility, Chinese immigrants still had constrained mobility.
Furthermore, the choice and level of detail of accessibility indicators in this paper is constrained as the indicators are to be estimated using outputs of the NVM-model, which provide a high spatial resolution but does not allow estimations of accessibility for different population segments.
In sum, our analysis has shown that over a broad range of metabolic complexity, historical contingency is not likely to strongly constrain the modulation of metabolic properties, or the accessibility of novel metabolic phenotypes.
