The legitimacy of public policies, such as in the realm of sustainability, depends not only on the choice of proper facilitating and constraining structures but also on the commitment to fair play and its follow-through.
The geometrically constrained structure mimicking PDX reactive loop is crucial for enzyme inhibition.
The reflected residual VQ, a type of multistage VQ, has constrained structure with multiple stages having small-size code-books.
In an effort to discover potent antibacterials based on the entropically favored 'bioactive conformation' approach, a series of novel tricyclic molecules mimicking the conformationally constrained structure of Linezolid is reported.
Compound 11 therefore represents a suitable lead compound for future drug development projects, due to its novel conformationally constrained structure, its "lead-like" properties and desirable affinity, efficacy and selectivity characteristics.
Attachment to a spatially constrained structure would also promote efficient use of required factors, with locally high concentrations at specific sites rather than diffusely spread throughout the nucleus.
The α-conotoxins are a class of disulfide rich peptide venoms isolated from cone snails, and are known for their highly constrained structures and resistance to enzymatic degradation.
The combination of pressure, which favors the population of folding intermediates relative to chemical denaturants; NMR, which allows their observation; and constrained structure-based simulations yield unparalleled insight into protein folding mechanisms.
6-Pyridone 2-carboxamides derived from ketoamides were synthesized as conformationally constrained structures resembling the well known peptidic μ-calpain inhibitor, MDL 28,170, and their μ-calpain inhibitory activities were evaluated.
In addition, we are interested in more pseudoknots that can be predicted in a similar way using a pipeline of constrained structures.
