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A particularly ambitious recent example is the Retropath tool for the principled design of entire metabolic circuits [ 44 ], based on constraining information about the metabolic capacities of the envisaged host organism (chassis) and the scope of available chemical reactions.
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Based on previous diagnostic studies about medical barriers [ 4, 5] researchers and policy makers in Guatemala concluded that providers routinely constrained information about family planning and lacked skills to select and organize the questions they asked and information they provided.
However, the simple scaling up of such results to explain conditions on a large field scale, across agricultural landscapes under varied management scenarios, or across landscapes made up of different types of ecosystems (agricultural, grassland, forest), is very much constrained by a lack of information about the spatiotemporal distribution of earthworm populations.
An important feature of our method is that it cannot only detect constrained elements, but it also provides information about the potential functional constraints associated with each base of the constrained sequences.
They give information about the enabling and constraining factors of legitimacy on the basis of interviews of the participants.
I will give particular attention to the local bispectrum which is tightly constrained by Planck giving us non-trivial information about the physics of the early universe.
These sections have not been constrained by geophysical investigations, which can provide significant information about the subsurface geometry.
Using a priori information about the source distribution can be beneficial for constraining the problem and improving the reconstruction.
The information about the missing wedge was used to constrain correlation during alignment of particles to the average, and appropriate Fourier component weighting was performed during generating the average at the end of each iteration.
While these models provide valuable information about the future of our planet, the resolution constrains the conclusions that can be drawn about smaller regions, such as individual cities, or regions with complex geography.
The pace of research is partly constrained by the number of observations that can be taken; gaps in information about the wind, pressure, and moisture content throughout the local atmosphere; and the computing power available for simulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com