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The program was constrained to maintain stereochemistry of the input structures but allowed to sample ring conformations.
At each level j, the scaling functions are defined as, begin{aligned} phi _j (x) = sum _{k in mathbb {Z}} a_k phi _{j-1} (2x - k), end{aligned} (4 and the wavelets are given by: begin{aligned} psi _j x) = sum _{k in mathbb {Z}} b_k phi _{j-1} (2x - k), end{aligned} (5 where x is the spatial coordinates and (a_k) and (b_k) are coefficients usually constrained to maintain basis orthogonality.
For the SKI and chemokine templates, the random sequences are constrained to maintain the conserved, native cysteines.
Local realignments were constrained to maintain the overlap between the secondary structure elements found in the MTase structures used as modeling templates, and predicted for HEN1.
Given the imbalanced nature of GS, the bootstrapping was constrained to maintain the same proportion of active versus inactive items as observed in the entire GS.
Local realignments were constrained to maintain the overlap between the secondary structure elements found in the template structures, and those predicted for the target.
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With a more realistic approach, we used a complete data set, including events with small amplitude, and we took in consideration the state of the geomagnetic field behind and ahead of SC, and we took as a main constrain to maintain coherence with the older lists.
In order to maintain effective arterial oxygenation, PaO2 is constrained to be higher than 8 kPa, with a desired value of 12 kPa.
Imagery choice was constrained by attempting to maintain between-scene temporal consistency [15] and minimising cloud cover and other detrimental atmospheric effects.
Models were constrained to include a maximum of three samples collected within 4 h after the intake to maintain clinical applicability for patients in the outpatient department.
The equations were constrained to include a maximum of three samples collected within 4 h after the intake to maintain clinical applicability.
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