Sentence examples for constrained to expression from inspiring English sources

Next, the model is constrained to expression data so that protein concentrations are subsumed in the Vmax values and chosen from typical concentrations in cancer cells, measured kinetic parameters, and measured concentrations of nutrients such as glucose, oxygen, and total intracellular adeno-nucleotide concentration.

For example, the transporter Vmax ranges included four orders of magnitude in the large population, but were constrained to ranges suggested by transporter expression profiles from Meier et al. in the small population.

For example, if selection acts to constrain gene expression levels to an optimal level but novel regulatory alleles persist with long sojourn times due to weak purifying selection, then compensatory regulatory evolution [44] may be common.

DOI: http://dx.doi.org/10.7554/eLife.05462.012 An active mode of dosage compensation is predicted to constrain expression in the face of underlying gene amplification, thereby buffering CNV.

To determine the roles of the TLS polymerases in replicating across C8-dG-ABA, we employed a siRNA knockdown approach to constrain their expression.

To demonstrate the importance of our novel approach, we investigated how much evidence of selectively constrained gene expression evolution we can detect between human and mouse.

Beerling points out that the genes for leaf morphogenesis were to a large extent already present in clubmosses, spikemosses and quillworts and proposes that high CO2 constrained the expression of this morphogenetic potential.

In this context, fundamental questions arise: how can the architecture of gene regulatory networks generate, make use of or be constrained by expression noise?

Each of them is a potential candidate from model correction and for the identification of new secondary metabolite biosynthesis genes with specifically constrained gene expression patterns.

This work is mainly based upon a metabolic model, which generally consists of metabolic reactions constrained by expression levels of metabolic genes or activation levels of enzymes.

Together, our morphological and molecular datasets indicate that the ER gene is required to constrain WUS mRNA expression in jba-1D/+ meristems.