The latter has also constrained studies at the whole muscle level, which additionally have to deal with the wide heterogeneity of muscle fibers and variations in size among different fiber types [ 13, 14, 15].
The inherent statistical uncertainty of case control studies involving just a few hundred cases and controls severely constrains study power to reliably identify genetic determinants conferring modest, but potentially important, risks.
While smooth retinotopy is constraining, studies suggest that it improves both wiring economy and the V1 population code read downstream.
We have constrained our study to the consideration of three cases based on CSG and OSG access methods and the reuse or not of the operator sites.
Heretofore, there have been a number of comparative studies for feature selection, but they have either considered settings with much smaller dimensionality than those occurring in current bioinformatics applications or constrained their study to a few real data sets.
Fourthly, the use of LYG as an outcome measure constrained the study to mortality/fatality analysis.
First, the number of cases was small because our case definition was restrictive, which constrained our study's power.
As a consequence, the researcher is constrained to study each one of the coexpressed gene sets individually, losing much of the potential that the technologies for obtaining gene expression arrays offer.
An advantage of genetic models such as FORKO is the ability to recapitulate specific physiological mechanisms involved in human reproductive aging; however, limitations such as potential effects of the mutation on brain development and function could introduce confounds or constrain study interpretations.
Yet, it is often ignored or indirectly constrained in studies of landscape evolution, as with the K erodibility parameter in stream-power models.
As a consequence, practical considerations have constrained the studies that have been conducted.
