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In fact, the number of transcription factors present in the genome is constrained by the limits set by coding theory: unlimited increase of the number of transcription factors capable of recognizing specific nucleotide sequences would lead to the increase of misrecognition errors (Itzkovitz et al. 2006).
Start by setting limits and household rules.
The design of the ship was constrained by the limits of the harbours at each end of the route; 49,000 tonnes was the largest that Calais and Dover could handle, though both are set to be expanded by 2015.
Fishermen say they are constrained by catch limits, but the judge said current rules had not restored depleted stocks.
Like a fantasy baseball team, a delegation put together this way is not constrained by the limits of geography.
A sports team, whether constrained by salary limits or not, should still seek to maximize its resources.
Despite their differences, both economists agree that few people are constrained by current limits on contributions to I.R.A.'s and 401(k) plans.
Why aggravate it?" Some teachers say they feel constrained by the limits, that the school board seems to be second-guessing their lesson planning.
Patients felt constrained by time limits and consultants did not actively encourage guidebook use.
The filmmaker's imagination was constrained by physical limits.
Unbridled will only be constrained by the limits of its volunteer rolls and its scarce funding.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com