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Business model innovators aren't constrained by existing business models.
One, unlike global companies, local leaders are not constrained by existing products or by preconceived notions about customer needs.
The US approach to defense against bioterrorism is necessarily constrained by existing legal frameworks.
The West Yorkshire leaders recognise that pursuing a Leeds city region deal brings administrative challenges, but that the scale of economic growth offered by devolution at this level should not be constrained by existing administrative boundaries.
The extent and pace of change may also be constrained by existing funding arrangements in the health system.
In that respect, the first priority should be to expand commuter rail service in Maryland and Virginia — service that is already stretched as far as it can go, constrained by existing tracks, bridges and stations.
Roboticists, or robot makers, have been constrained by existing off-the-shelf parts, until recently, can now design and print their own parts and shells with affordable or free design tools and the increasingly affordable 3D printers.
But each time we have a new technical platform -- for example, mobile phones or a change of web standards -- it tends to be the case that a new entrant who is not constrained by existing operations grows much faster.
The approach applied in this study delivers a perspective that is not constrained by existing assumptions about the organization of plant processes.
Such topology-based designation of modules is not constrained by existing annotation of pathways, and allows finding novel disease-specific modules.
We chose a qualitative approach to help us to access the content and nature of participants' views without being constrained by existing constructs such as expectancies [ 23].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com