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"Parliament cannot expect the government to set out its negotiating hand because that would not be in the national interest, nor should it constrain the flexibility of the government to negotiate on our behalf to get the best deal," she said.
In normal cells, this S/MAR may constrain the flexibility of the region by anchoring it to the nuclear matrix, thus restricting interactions of adjacent sequences in the three dimensional nuclear space.
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A binding approval regime of the type proposed for the UK would have a significant impact on US pay practices, constraining the flexibility of directors to react to changing situations and imposing a healthy quantum of new governance and legal considerations for US public companies.
The analysis of the rigid body fitting indicates that not only the surface-surface interaction between neighbouring subunits but also the presence of the inter-molecular isopeptide bond constrains the flexibility of the pilus.
The positions of the two prolines and the third key anchor residues ([RKY] or [RK], respectively) were relatively fixed in the structure, thereby also constraining the flexibility of the motif residues between them (RMSD 3.6±2.3Å).
Although it constrains the flexibility of the search, this helps to avoid large disparities in the number of clusters for rows and columns (which ideally should be equal) despite the fact that the truncated DAG matrix generally has far more rows than columns.
A substitution at 4-indole position was introduced to constrain the conformational flexibility of the inhibitor to the bioactive conformation exhibited by X-ray structures so that entropic penalty was decreased.
The overlay shows that all regions of the circular chromosome are highly connected both by Y2H interactions and by the predicted functional connections clearly indicating that the given genome structure does not constrain the overall flexibility of physical interconnections.
The mutations Q/R associated to L/M seem to induce constrains in the flexibility of protein structure except for the regions designated as switches.
A neighborhood around each anchor can be added to increase the flexibility of the constrained alignment.
Should we constrain the march of technology across the professions?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com