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We conclude with an overview of current results using the seismological technique that constrain parameters such as the equation of state and crust structure.
We suggest that this two-step approach should be used to identify important parameters in global LSMs, so that observations to constrain parameters can be used more efficiently in a subsequent parameter estimation step.
In addition to a probabilistic estimate of the prediction, an added value of emulator-assisted ABC inference is providing information on the extent to which observations can constrain parameters and predictions, as well as the flexibility to include various quantitative and qualitative parameter constraining information.
Note that the back-projection approach provides location and timing of relative energy release during an earthquake, but cannot constrain parameters such as dip of the fault or absolute slip (e.g., Ishii et al., 2005, 2007).
The first ones constrain parameters to remain constant.
Observations are required to constrain parameters used in models and to validate model predictions.
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Unidentifiable parameters were given physiologically justified values, with knowledge on relative insulin clearance rates used to constrain parameter values.
The model has a direct dependence on the estimate of specific yield, a difficult to constrain parameter, which we estimate from previously published soil analyses.
As new measurements become available, these can be incorporated to further constrain parameter values.
Parameter inference yields important information on the extent to which the data and the model constrain parameter values.
This uncertainty could be reduced by conducting experiments to measure or constrain parameter estimates, which may lead to a more focused set of expectations from the trial due to greater certainty of the underlying biology and its connection to disease.
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