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These concerns can constrain initiation of treatment for all women with indicated need, or may impede sustaining therapy over the recommended timeline established for the particular regimen, once treatment has been initiated [ 15, 16].
We suggest that failure to constrain initiation may allow greater flexibility and plasticity in these cell types, and that such flexibility may be lost with the imposition of spatial constraint as cells differentiate.
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This approach allows us to map the parameter regimes in which high codon adaptation is expected to increase transgene protein yield and by what mechanisms revealing the critical role of free ribosomes in constraining initiation and protein production.
On the other hand, Lynch et al. (2005) proposed that the length of the 5'UTR is driven mainly by random genetic drift and mutational processes that cause stochastic turnover in transcription-initiation sites and premature start codons, combined with a selective constrain against the premature initiation of translation.
It has been suggested that +4G may have little to do with initiation site recognition, but is constrained by the requirement for particular type of amino acid residue at the N-terminus of the protein [9].
Government-sanctioned outbound flows are less problematic than patient-initiated flows but are constrained by low approval rates, which may increase patient initiation.
The latter aims to compress the irresolvable roughness of rupture front, which is not well constrained because of the intrinsic trade-off between rupture initiation time and starting time (Ji et al., 2003).
The fracture initiation and propagation during hydraulic fracturing is primary constrained by local stress field, hydraulic pressure magnitude, coal properties, and natural fractures.
The origin of such sex differences remains unclear, although it has been suggested that multivalent formation may be constrained during female meiosis due to greater specificity in the initiation of chromosome pairing relative to males [ 9].
All three of these species destroy nanoscale Si structures; therefore, the initiation step and etch rate of each reaction must not be constrained by quantum confinement.
This suggests that initiation or maintenance of infestation in the former groups is somehow constrained.
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