Sentence examples for constrain gene expression from inspiring English sources

For example, if selection acts to constrain gene expression levels to an optimal level but novel regulatory alleles persist with long sojourn times due to weak purifying selection, then compensatory regulatory evolution [44] may be common.

Each of them is a potential candidate from model correction and for the identification of new secondary metabolite biosynthesis genes with specifically constrained gene expression patterns.

To demonstrate the importance of our novel approach, we investigated how much evidence of selectively constrained gene expression evolution we can detect between human and mouse.

By constraining the gene expression, miRNAs renders phenotypic traits governed by (spatiotemporal) gene expression more "heritable", and thereby "evolvable" [ 22].

This coupling was found to be particularly strong for genes with specific promoter architecture (TATA box and high nucleosome occupancy) but weak for genes in which high noise may be detrimental (e.g., essential genes), suggesting that noise plasticity coupling is an evolvable trait in yeast and may constrain evolution of gene expression and promoter usage.

Finally, we use our approach to provide clear evidence for constrained evolution of gene expression between mouse and human.

Increased methylation may constrain plasticity in subsequent gene expression and restrict the range of stress adaptation responses possible in affected individuals, thus increasing their risk for adult-onset diseases.

Predicted fluxes are given for the gene expression constrained approach, introduced here, and the standard FBA method that relies upon maximisation of biomass.

Specifically, the gene expression constrained method provides good fits to the measured flux to exit data at both 75%and85%5% growth level R = 0.87 and R = 0.96 respectively), while the standard FBA method provides a much poorer fit.

The gene expression constraining approach can also be considered as a filter: given that the experimental data can be taken as representative of the fluxes, the random errors associated with such data should cancel out at a genome-wide level.

Other factors such as selection against large alterations in coding regions and associated sequences that may play a role in gene expression could constrain SSR expansion or contraction.