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Introduction of a transient or constitutive source of SB11 transposase activates T2/OncZ excision from the concatemer and genome-wide re-integration in somatic tissues.
Specifically, under physiological conditions, the redox complexes I-III of the mitochondrial electron transport chain are the major constitutive source, converting up to 5% of molecular O2 to O2⋅− [83].
This could be achieved by introducing or tuning a constitutive source of y output (i.e., one that is not regulated by the input signal x).
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The results demonstrate that transient or constitutive sources of SB11 transposase effectively mobilize transposition from a stable T2/OncZ concatemer followed by genome-wide re-integration.
It is likely that the methods for nasal NO measurement need to be substantially standardized because of the high nasal NO levels from constitutive sources in the nose [ 183].
Where a promoter sequence alteration or methylation of MLH1 was identified, we requested a second normal DNA sample from the proband (preferably from a different tissue source), constitutive DNA from relatives, and a copy of the pedigree.
Thus, the boundary values, the constitutive equation, and the source field Q are (G, h -invariant.
The model uses atomistic calculations as the sole source of constitutive information, with no parameter fitting of any kind to experimental data.
The symmetry group G is, and the boundary values, source J, constitutive equation in terms of the operator μ, and the cohomology conditions for H and B are all G-invariant.
Another source of constitutive regulatory elements is cryptic gene-regulatory elements.
We selected microarrays about NSCs, neurogenesis, glias and central nervous system (CNS), due to that NSCs are the principal source of constitutive neurogenesis and glias in the CNS.
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