Sentence examples for constitutive release from inspiring English sources
The aim of this study was to correlate constitutive release of cytokine(s) from unstimulated cells, at different stages of development, within a 3-dimensional (3D) organotypic ex vivo produced oral mucosa equivalent (EVPOME) to be used for intraoral grafting, with oral keratinocyte cell viability of the EVPOME.
Collectively, these results indicate that SPWs can be triggered by constitutive release from the mossy fibers.
The constitutive release argument predicts that evoked activity in the mossy fibers will trigger a sharp wave.
In contrast, a constitutive release of IL-4 from pancreatic β-cells is able to prevent insulitis development in NOD-IL-4 transgenic mice [34].
Together, these results indicate that constitutive release from the mossy fiber terminal boutons regulates the incidence of SPWs and their contribution to information processing in hippocampus.
These results provide the first evidence that increases and decreases in constitutive release are accompanied by corresponding changes in SPW activity.
In addition to these differences in constitutive mediator release, there were key differences in release following stimulation.
Although accumulation of IP3Rs through lateral diffusion in ER-lysosome MCSs has not yet been demonstrated directly, constitutive Ca2+ release mediated by local enriched IP3Rs has been reported on ER-mitochondrial MCSs (Szabadkai et al., 2006; Cardenas et al., 2010).
We then argued that, in analogy to what has been found for Dkk-1 in MM, constitutive noggin release by osteolytic cancer cells might contribute, through inhibition of bone formation, to the osteolytic lesion in bone metastases of solid cancers.
Ins(1,4,5) P3Rs mediate a constitutive Ca2+ release toward mitochondria for assuring an appropriate energy production, which represses AMPK activity and hence keeps autophagy at low levels.
These observations suggest a mechanism in which constitutive Ca2+ release through IP3Rs fuels into the mitochondria, thereby augmenting mitochondrial bio-energetics and ATP production [ 54].
