Sentence examples for constitutive exposure from inspiring English sources

A CD4-independent version of the X4 human immunodeficiency virus type 1 (HIV-1) HXBc2 envelope (Env) protein, termed 8x, mediates infection of CD4-negative, CXCR4-positive cells, binds directly to CXCR4 in the absence of CD4 due to constitutive exposure of a conserved coreceptor binding site in the gp120 subunit, and is more sensitive to antibody-mediated neutralization.

We employed stable MDA/RLN2 transfectants to investigate the long-term effects of constitutive exposure to relaxin, which is most likely to be equivalent to the situation in breast tumours.

As BAK constitutively localizes to the mitochondria and the α1/α6 binding site is not as pronounced, it has been proposed that BAK can bypass this activation step resulting in constitutive exposure of the N terminus (Kim et al., 2009).

These results suggested that relaxin's short-term effects on cell motility were dependent on S100A4 and that the down-regulation of S100A4 following constitutive exposure to RLN2 was responsible for the reduced cell motility and migration in stable MDA/RLNs transfectants.

Although modest changes are common in constitutive Cyp1b1, environmental exposures infrequently change Comt expression; one rat model of aryl hydrocarbon exposure showed decreased hepatic Comt expression (Desaulniers et al. 2005).

However, with longer exposures, constitutive CTF1 generation was visualized.

Thus, any recycled receptor undergoing constitutive internalization during palonosetron exposure would remain inhibited.

Observed health effects from low dose, low dose-rate radiation exposures include less constitutive damage,and increased resistance to damage from subsequent radiation exposures through an adaptive response.

The population at Puerto Montt inhabits the northern limit of the Nacella distribution range, and the physiologically possible strength of the HSR in response to air exposure, supported by constitutive production of Hsp70B, are putative limiting factors in colonization of warmer intertidal habitats.

In addition to tolerating constitutive extracellular or metabolic ROS exposures, cells need to resist acute oxidative challenges, for example from inflammation-induced oxidative bursts, nutritional challenges, exposure to electrophilic xenobiotics or transient pathologic perturbations of mitochondrial electron transport [ 3, 4].

Our results indicate that, under the insecticide exposure conditions we used, constitutive over-expression of metabolic genes play more of a role in insect survival than induction of members of these gene families.