The phrase "constitutive event" is grammatically correct and can be used in written English.
It refers to a significant event or occurrence that helps to define or establish something. Example: The signing of the Declaration of Independence was a constitutive event in the history of the United States, marking the country's birth and establishing its fundamental principles.
Moreover, cofactor-activated phosphorylation of Gro/TLE is dependent on a previous constitutive phosphorylation event mediated by protein kinase CK2 [27].
The in vivo kinetics of splicing has been suggested to be very rapid, at least for efficient constitutive splicing events, showing halflives of 0.4 7.5 minutes [27].
Differentially affected constitutive splicing events in prmt5 and prmt4a 4b mutants, relative to the wild-type.
triPOD identified 11 events with highly skewed BAFs and LRRs that were suggestive of inherited CNVs, and 10 of 11 CNVs were also present in a parent, substantiating the constitutive nature of the event and that the event was inherited and therefore not mosaic, whereas the remaining event clustered with the inherited events was considered likely constitutive.
The lack of a dramatic phenotype may be due to compensatory mechanisms by co-expressed SNARE isoforms playing a similar role (genetic redundancy) or in some cases because the roles of these proteins are confined to regulated exocytosis rather than constitutive protein trafficking events.
A smaller number of putative mosaic detections arose from misclassification of constitutive copy number events, mainly duplications, as being mosaic.
14, 15 Since activation of the PI3K/AKT cascade promotes mTOR activity, many tumor types exhibit high levels of mTOR activity due to constitutive upstream signaling events.
These CNVs had extreme B-allele deviations and LRR values that clustered with inherited duplications and not with other de novo mosaic events, supporting the classification of these events as constitutive (Supplementary Material, Fig. S1, Supplementary Material, DDD & SFHS Constitutive CNV Filtering).
These oncogenic events result in constitutive ERK pathway activation.
Average splice site scores and p-values for alternative splicing events and constitutive splicing are shown here.
