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The phosphomimetic mutation, FLAG MST3(T178D), resulted in the constitutive appearance of 58 kDa FLAG MST3(T178D), suggesting stimulation of cis-autokinase activity, though 54 kDa FLAG MST3(T178D) was never completely lost.
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Mouse models of HPS1 and HPS2 have AECs with abnormal appearance, constitutive activation of lung macrophages (Young et al., 2006) and basal lung inflammation (Atochina-Vasserman et al., 2011).
Furthermore, the rate of nuclear export exceeds the rate of nuclear import, giving the appearance of constitutive localization of SIRT2 in the cytoplasm.
Constitutive expression of CD106 appears to be a characteristic appearance of nurse cell lines, permitting them to be distinguished from fibroblasts [ 7].
Decreased Dab2 expression in normal mammary epithelial cells leads to the appearance of a constitutive EMT phenotype.
This new state is expected to be the predominant intermediate on unstimulated plasma membranes containing constitutive PS and PIP2, prior to the appearance of a DAG signal.
Future challenges will also aim to identify advantages and disadvantages of the abovementioned constitutive modules trajectory formation, the shape model, and the appearance model.
mice by constitutive Fgf signaling, which ultimately leads to the appearance of malignant tumors.
The early appearance of senescent cells in the epidermis of constitutive Sod2-deficient mice, as opposed to their later appearance in connective tissues of conditional Sod2-deficient mice might be attributed to the location of epidermal cells at the interface between the body and environment.
There was a modest time delay in the appearance of visual symptoms (data not shown) and the abrogation of constitutive luciferase expression when treated with gentamicin at 100 µg/ml.
The constitutive deficiency of defined molecular net components had some phenotypic effects on the appearance but not on the number of PNs in all tested mouse strains.
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