Sentence examples for constitutional variation from inspiring English sources

In addition, a constitutional variation in the FOXL2 3'UTR was found to cosegregate with BPES in a large Chinese pedigree [21], and might disturb FOXL2 mRNA stability.

Moreover, the great range of ADF might simply reflect the constitutional variation within the population.

It is also recommended to investigate other approaches in larger cohort constitutional variations with different phenotypic forms of intra-oral soft and hard tissues of different ethnic groups similar to the study by Patil et al. [31].

Moreover, the sets were made the more homogeneous possible in order to minimize the undesiderable effects of the inter-tumoural genetic differences due to the intrinsic constitutional variations among individuals.

Thus, an understanding of human population variability and the role of constitutional genetic variation remains elusive.

These findings suggest a direct relationship between constitutional genomic variation and tumour genome evolution.

We undertook this study to assess the role of constitutional genetic variation in the human aromatase gene (Cyp19) in the development of this disease.

Our conclusion is that constitutional genetic variation at the Cyp19 locus is associated with the risk of developing breast cancer, with the 171-bp allele serving as the high-risk allele.

DFL harbors the t(14,18)(IGH-BCL2) translocation, which is also a common feature of NFL. 3, 6 While this translocation alone is considered necessary but insufficient to cause FL, it provides B cells with a survival advantage, allowing them to accumulate additional genomic alterations, host constitutional genetic variation, and survive in different microenvironments.

An example of the potential of this approach is provided by recent data suggesting that constitutional allelic variation in UDP-glucuronosyltransferase, a protein involved in the metabolism of irinotecan, may predict response and toxicity in patients with advanced CRC treated with capecitabine/irinotecan (Carlini et al, 2005).

Constitutional copy number variations associated with NB susceptibility have been described for LMO1 at 11p15.4 as well as the NBPF23 gene at 1q21.1 (Diskin et al, 2009; Wang et al, 2011).