Sentence examples for constitutional predisposition from inspiring English sources

Yet, the present results are the first to demonstrate that CO2 dose dependently activates a condition identical to panic in healthy volunteers, regardless of any constitutional predisposition to psychiatric pathology.

Our results illustrate the complexity of constitutional predisposition to cancer, including that associated with TP53 mutations.

Both Goldstein [ 10] and Bonhoeffer [ 1] thought that the psychological impact of war could not cause genuine epilepsy in an individual without a constitutional predisposition.

The first factor in this theoretical framework is that people with insomnia have a constitutional predisposition to develop a chronic sleep problem.

T-bil includes both unconjugated and conjugated bilirubin, and the T-bil value can be affected by a number of factors including prehepatic or posthepatic disorders, hemolysis, and constitutional predisposition.

Although these results are consistent with constitutional predisposition to metastatic disease and suggest that the inherited susceptibilities for tumors that disseminate to the LNs is different than those that metastasize directly distant organs, the mechanisms used are currently unknown.

The identification of low-penetrance susceptibility alleles at 7p12.2 (IKZF1), 9p12 (CDKN2A/ CDKN2B), 10q21.2 (andD5B) and 14q11.2 (CEBPE) in genes involved in transcriptional regulation and differentiation of B-lymphocyte progenitors, highlights the role of constitutional genetic predisposition in childhood ALL onset.

Therefore, despite the unknown mechanisms of lipid-associated SNPs, their effects might reflect the relative pathological predisposition of each constitutional type.

We here describe a patient affected by mosaic Klinefelter syndrome and by rhabdoid tumor predisposition syndrome caused by constitutional SMARCB1/INI1 heterozygous mutation c.118C>T (Arg40X).

Notably, these tumors also represent the sole manifestation of a heritable cancer predisposition syndrome caused by constitutional alterations of SMARCB1/INI1 tumor suppressor gene [ 5, 6].

Here, we describe a novel nonchromosome 3 constitutional translocation associated with an inherited predisposition to RCC and investigate the function and role in sporadic renal tumorigenesis of UBE2QL1, a previously uncharacterized gene that is disrupted by the translocation.