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Despite this progress, there are also large areas from which little information is available, thus constituting significant paleo-geographic gaps in the last interglacial record.
The treatments follow the ancient Hippocratic, Hellenistic and Roman traditions and influence medieval European medicine, thus constituting significant roots of obstetrics.
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Debate itself constitutes significant change.
Both these processes constitute significant engines of change.
There are also disagreements over what constitutes "significant" impact.
I don't think that, in itself, constitutes significant inter-personal dysfunction".
Szarkowski's notion of what constituted "significant fact" was both fiercely discerning and radically democratised.
But scientists say there was debate in their ranks over what might constitute "significant chemical change".
If implemented — admittedly a big if — this would constitute significant progress.
Inventions in the field of space engineering continuously constitute significant part of the innovative space market.
For these reasons, hydronomic works, by nature, constitute significant protection-environmental works.
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