"[F]oreclosure filings have increased dramatically while HAMP has been in place, with permanent modifications constituting just a few drops in an ocean of foreclosure filings".
Thus, although changes to cell identity can be achieved by ectopic expression of key TFs alone, the efficiency of conversion remains painfully low, with existing chromatin modifications constituting a well-described barrier to the reprogramming process (Mikkelsen et al, 2008; Pasque et al, 2012; Chen et al, 2013b; Gaspar-Maia et al, 2013; Sridharan et al, 2013).
If they send in a check for this new lower amount,that constitutes a modification.
Does using a black market smart card really constitute "device modification?" Lawyers live for this sort of semantic hair-splitting.
Having established what constitutes disease modification through pharmacologic intervention, it was necessary for the group to identify the most appropriate markers of disease status that can be used to monitor this process.
If we adopt Scanlon's recent account of blame (2008), then perhaps we can say that some wrongs are none of our business because they don't impair any of our relationships, and hence don't render appropriate any blame-constituting modifications in those relationships.
Isotactic polypropylene (iPP) rich in β crystal modification (constituting 92% of crystalline phase) was deformed by the plane-strain compression with constant true strain rate, at room temperature.
The activity of histones is intimately regulated via the broad range of reversible, enzymatically catalyzed posttranslational modifications (PTMs) constituting a specific histone code.
Epigenetic modifications, such as DNA methylation and histone modifications, constitute an additional layer regulating gene expression and thus effecting phenotypes and the development of various states of disease [ 11].
The final set of modifications constituted the fitting of new injectors and Automatic Warning System (AWS) equipment in 1957 and 1959 respectively.
Although these oxidative modifications constituted a minor fraction, compared to the NEM labeling, the precursor ion of each oxidative population was clearly identified in Figure 1B.
