We analysed BG values from 15009 samples from 494 patients obtained during the 20 months before introduction of the algorithm, constituting a mean of 750 samples per month.
QoL-AGHDAutility in patients before GH treatment differed from the expected population values [0·67 (SD 0·174) vs. 0·85 (SD 0·038), P < 0·0001], constituting a mean deficit of –0·19 (SD 0·168).
QoL measured by QoL-AGHDAutility in patients before commencement of GH treatment differed significantly from the expected values calculated from the sample of the general population [0·67 (SD 0·174) vs. 0·85 (SD 0·038), P < 0·0001], constituting a mean deficit of –0·19 (SD 0·168).
In turn, this enabled benefits to be reaped from other, more recent, sources of growth meaning that stabilization policies alone no longer constituted a means of additional growth.
The voluntary termination of pregnancy must under no circumstances constitute a means of birth control.
Design of water-soluble prodrugs may constitute a means to improve the oral bioavailability of drugs suffering from dissolution rate-limited absorption.
Far from being cabals of ambitious malcontents, parties constituted a means by which men of honour might act in concert for the public good, not least as a constraint on royal whim.
Recirculating flow near a static contact line, encountered in the production and deposition of thin liquid coatings, is undesirable since it constitutes a means by which process defects can arise.
Similarly, the Court of Appeals in Verdugo reasoned that international abductions violate the "purpose" of the Treaty, stating that "[t]he requirements extradition treaties impose constitute a means of safeguarding the sovereignty of the signatory nations, as well as ensuring the fair treatment of individuals". 939 F.2d, at 1350.
