While support in protein folding by molecular chaperones is extremely efficient for endogenous polypeptides, it often fails for recombinant proteins in a bacterial host, thus constituting a major hurdle for protein research and biotechnology.
Similarly, the fact he has only one year outstanding on his Sunderland contract dictates that compensation does not constitute a major hurdle either.
The high resistance of biomass polysaccharides, most notably that of cellulose, constitutes a main hurdle any viable process design must overcome3, 4.
We hung on to our own beliefs that it should be absolutely empowering, foster maximum self-sufficiency in a short period of time and definitely focus on job placements, since this last step constitutes a major hurdle for most employment programs out there.
In addition, locusts appear to have a very big genome (estimated 2 3 times larger than the human genome [8]), which constitutes a major hurdle to completely sequence it.
Thus, region-specific administration may be necessary for full efficacy, and this constitutes a major hurdle for noninvasive peripheral administration.
The lack of these genes might constitute a major hurdle for the switch from animal to plant parasitism, at least in case of (hemi- biotrophic species.
This clearly suggests that drug resistance, whether intrinsic or acquired over time, constitutes a major hurdle to overcome for the successful treatment of breast cancer.
Health workers interviewed in our study consistently argued that their salary was too low to make ends meet and that children's school fees in particular constitute a financial hurdle.
Furthermore, data generated with such technology should be presented in such a way that the presence of cells other than cancer cells in the samples would not constitute an insurmountable hurdle.
Another technical hurdle is the legal requirement that the Singaporean justice system recognise the allegations against Mr Tan as constituting a crime locally.
