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The persistence of infectious biomolecules in soil constitutes a substantial challenge.
Thus it constitutes a substantial challenge for the health care system and causes considerable direct and indirect costs [ 3].
Despite useful methodological developments performing routine modelling tasks with a multi-parameter model still constitutes a substantial challenge.
Accurate projection of known carbohydrate catabolic pathways across diverse bacteria with complete genomes constitutes a substantial challenge due to frequent variations in components of these pathways.
An accurate projection of this knowledge across the growing variety of divergent bacteria with completely sequenced genomes constitutes a substantial challenge.
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As already mentioned, blinding constitutes a substantial methodological challenge in rTMS studies.
Uncertainty propagation analysis in engineering systems constitutes a significant challenge.
Uncontrolled hypertension constitutes a significant challenge throughout the world.
The blood brain barrier constitutes a real challenge for delivering exogenous molecules to the brain.
Treatment of relapsed/refractory infant ALL constitutes a significant challenge as there is no defined therapy.
This constitutes a substantial breakaway from the established boundary between explicit and implicit content.
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