Sentence examples for constitutes a significant obstacle from inspiring English sources

Biometal limitation constitutes a significant obstacle for bacterial pathogens to establish infection in vertebrate hosts [59], [60], [64].

Considering that the purpose of data sharing is to maximize data usage [ 33], this potential gridlock problem constitutes a significant obstacle to sustainability.

The complexity of the At Home/Chez Soi project, however, constituted a significant obstacle to its implementation [ 16].

On the other hand, because such antigens are subjected to a great evolutionary pressure, a high level of sequence heterogeneity is expected within natural populations, which may constitute a significant obstacle to development of effective vaccines.

The singing, of course, constitutes a significant proportion of the film.

ATI's payment "constitutes a significant penalty for the acknowledged misconduct," the commission said.

Tourism alone constitutes a significant portion of this amount annually.

But cable constitutes a "significant" threat, according to Deutsche Bank.

Uncertainty propagation analysis in engineering systems constitutes a significant challenge.

Uncontrolled hypertension constitutes a significant challenge throughout the world.

The killing of Osama bin Laden constitutes a significant victory over global terrorism.