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A wide variety of chemotherapeutic agents were shown to stabilize p53 and, conversely, loss of p53 constitutes a principle mechanism of cancer resistance towards chemotherapy [33], [34].
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In this condition, the extraordinarily high concentration of tissue factor at the placenta site may constitute a principle of treatment as it activates coagulation very effectively.
In modern health care, it is commonly understood and generally accepted that the principle of beneficence constitutes a foundational principle of the patient-provider relationship [ 15].
The mandatory bid rule had been "widely adopted across the different groups of countries by 2004". Member States agree that the "equal treatment rule constitutes a fundamental principle of corporate law". There is also gradual convergence towards the adoption of the "squeeze out" rules.
It is worth noting that the deliberation of trialists to selectively recruit Ph chromosome-positive patients was unprecedented and set the stage for genetically based patient stratification, which today constitutes a cardinal principle in targeted trial design.
As Rawls sees it, the difference principle constitutes a public recognition of the principle of reciprocity: the basic structure is to be arranged such that no social group advances at the cost of another (2001: 122-24).
The current work constitutes a proof of principle that predictability of responses in an in vitro system from one species is feasible to some extent given responses from another species.
The implementation of the whole process of neuronal culture and subsequent activity monitoring constitutes a proof-of-principle experiment for the development of neuroelectronic systems for signal processing studies adapted to low-density neuronal cultures.
These are features typically observed in viral quasispecies approaching extinction during lethal mutagenesis which constitutes a proof-of-principle for this antiviral strategy.
Our use of COLMAR query for assignment of compounds present in multiple TOCSY spectra constitutes a proof-of-principle demonstration of how metabolomic analysis can be streamlined by integrating multi-2D statistical pattern recognition with informatics tools for compound assignment.
He argued that Kant's ethics lack any content and so cannot constitute a supreme principle of morality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com