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The occurrence of PEH years after breast irradiation constitutes a pathological and clinical diagnostic challenge because angiosarcoma is far more common in this setting.
However, the relatively few teeth that appeared with pockets ≥4 mm among the younger dogs support our contention that we have not applied an unduly liberal definition of what constitutes a "pathological" pocket depth among dogs.
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Amyloid-beta (Aβ) deposition in brain parenchyma and blood vessels constitutes a major pathological hallmark of AD [ 1].
ROS constitute a major pathological factor causing many serious diseases, including cancer and neurodegenerative disorders [32].
The type of proposed interventions changed as the surgeons were becoming aware that DD constituted a separate pathological entity which must be eliminated to obviate symptoms.
Consequently, this shift from mesial to lateral premotor loops has been suggested to constitute a core pathological or compensatory mechanism related to the impairment of internally generated as compared to externally cued movements in patients (Ceballos-Baumann, 2003; Grafton, 2004; Rowe et al., 2010).
At present, the clinical utility of changes in retinal vascular architecture is limited, as it remains unknown what constitutes an abnormal or pathological value of these retinal vascular parameters.
To determine how the overall ECM architecture of a tissue as complex as the atheroma may change under varying pathological conditions constitutes a great technical challenge.
ER stress constitutes a physiological as well as pathological stress stimulus, which when overwhelming, can lead to apoptotic death of the damaged cell.
Although secondary HBP (resulting from pathological insults) constitutes a higher proportion of HBP cases in children than in adults, primary HBP is still commoner than secondary HBP in children in developed countries, with obesity playing a major role [ 8].
Modulation of Dyrk1a by miR-199b constitutes a feed forward mechanism that enhances pathological cardiomyocyte hypertrophy processes [ 97].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com