Sentence examples for constitutes a major problem from inspiring English sources

This constitutes a major problem with titanium-based implantable devices which are very expensive and thus in short supply.

Cervical cancer caused by high-risk human papillomavirus (HPV) infection constitutes a major problem in women's health worldwide and is the fifth leading cause of cancer deaths among females[1, 2].

The highly variable nature of PCa progression constitutes a major problem in clinical management of the individual patient.

Today, resistance to this affordable drug constitutes a major problem in the fight against malaria in most of the malaria endemic countries [12].

Clonal selection of resistant metastatic cancer cells constitutes a major problem for clinical treatments in which therapeutic options become exhausted over time.

Selection bias constitutes a major problem when participants are recruited; for example, from the outpatient departments of university hospitals.

Medication errors constitute a major problem in all hospitals.

E-book piracy does not yet constitute a major problem in the United States, but there are warning signs.

The oscillations occurring during the drilling process constitute a major problem to solve in the oil extraction industry.

The balance decline, the appearance of fear of falling, and the resulting loss of autonomy, constitute a major problem for public health.

Thermal budget constraints, however, still constitute a major problem when back-end integration is pursued.