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"constitutes a key issue" is a grammatically correct and commonly used phrase in written English.
It is typically used to describe something that is an important or central problem or topic being discussed. Example: The lack of affordable housing constitutes a key issue for low-income families in this city.
Exact(1)
In food industries, managing sensory properties from the fabrication stage in an automatic framework constitutes a key issue for companies but is no easy task.
Similar(59)
These results demonstrate the seismic-resistant behavior of timber-framed structures with infill and constitute a key issue for the promotion of such constructions in developing countries.
Cellular and molecular mechanisms involved in the development of topographic ordered connections in the central nervous system (CNS) constitute a key issue in neurobiology because neural connectivities are the base of the CNS normal function.
In addition to issues of penetration, language constitutes a key feature that shapes openness and access.
Endogeneity constitutes a key concern in the relationship between external sanctions and audit quality.
The Youth Movement constitutes a key political constituency that may eventually form a distinct party.
Its prevention therefore constitutes a key goal of management.
Toxicity monitoring may constitute a substantial proportion of the cost associated with preventive therapy, and economic, human, and financial sustainability may represent a key issue in limiting a wide implementation of programmatic LTBI management.
Should pollution should be a key issue?
Price will be a key issue, too.
So, susceptibility may be a key issue.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com