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Therefore, seeking for more efficient designs of high conductivity pathways ('inserts'), embedded into a heat generating body constitutes a formidable challenge.
Thus, the in-depth investigation of cell death and its mechanisms constitutes a formidable challenge for fundamental and applied biomedical research, and has tremendous implications for the development of novel therapeutic strategies.
This all constitutes a formidable challenge for a Pakistani state that is either unable or unwilling to quell the less multifaceted anti-government insurgency it faces today.
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The gentle grasping and manipulation of objects in dense un-structured environments, such as the agricultural, food processing, or home environments constitute a formidable challenge for robotic systems.
That constituted a formidable challenge to the orthodox view that nuclear weapons exercised a stabilizing deterrence on international misbehaviour and were a reassurance to allies of the United States, who faced preponderant Soviet conventional forces.
The enormous diversity of proteoforms produces tremendous complexity within cellular proteomes, facilitates intricate networks of molecular interactions, and constitutes a formidable analytical challenge for biomedical researchers.
The unknown inertia properties of target spacecraft in the system constitute a formidable technical challenge for controller design.
Still, that can be a formidable challenge.
That is likely to be a formidable challenge.
Ukraine on its own would be a formidable challenge.
But explaining why turns out to be a formidable challenge.
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