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Modulation of Dyrk1a by miR-199b constitutes a feed forward mechanism that enhances pathological cardiomyocyte hypertrophy processes [ 97].
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The TGFβ1 PINK1 interaction could constitute a feed forward cycle that favors the perpetuation of fibrosis that is characteristic of the IPF lung.
The evidence of a interplay between mitochondrial and NADPH oxidase-derived ROS constitutes a feed-forward cycle in which mitochondrial ROS increase NADPH oxidase-dependent ROS production that in turn increases mitochondrial ROS generation, in a vicious cycle.
Simply over-expressing Caspases in yeast is sufficient to lead to their activation in many cases [11], [12], [13], [14], presumably because upstream initiator Caspases are typically activated by dimerization and also because many Caspases are capable of cleaving and activating their zymogen forms, constituting a feed-forward mechanism for amplifying protease signaling (reviewed in [15]).
Thus, these processes would constitute a feed-forward loop that can contribute to genetic divergence by fueling the birth of new genes and accelerating their evolution.
Lu et al (2005) have proposed that various glucose metabolites promote HIF stabilisation and reduced expression of TCA cycle enzymes, thus constituting a feed-forward signalling mechanism favouring continued dependence on glycolysis as an energy source.
Thus, the mutp53-HSF1 constitutesstitutes a novel mutp53 gain-of-function, whereby mutp53 initiates a feed forward loop that enhances EGFR/ErbB2 signaling and amplifies HSF1-induced transcriptional program, imparting an enhanced proteotoxic defense.
Robots use a feed forward neural network controller.
A feed forward neural network has no feedback paths and inputs are processed in the forward direction.
Watetakarn [11] presented a forecast of solar irradiation using a feed forward neural network.
A back propagation (BP) NN is used which is a feed forward NN.
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