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The fact that the binding is nealy irreversible, however, constitutes a drawback in term of the isolation and purification of intact biomolecules.
Nevertheless, in some cases this high stiffness constitutes a drawback because it could reduce the fatigue resistance offered by these materials, leading to a premature appearance of cracks in the pavement, which decreases its service life.
The highest MCA is found for Mn2PtSn (3.04 meV) but its low TC (374 K) constitutes a drawback.
As this coincidence may not be a rarity in other, differently selected, populations, it constitutes a drawback of this kind of model.
Since not all cytokines result in a biological response, the potential biological incompatibility of tested compounds constitutes a drawback of our model.
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It should be noted that this limited leakiness nevertheless represents specific labeling of beta cells, and does not constitute a drawback in the context of this study.
The EF1 alpha translation elongation factor was identified as a possible partner for several different types of proteins that were assayed in the two hybrid system and interactions with EF1alpha have often been considered as the result of a technical artifact that constitute a drawback of the selective procedure.
The higher proportion of femoral procedures in the LM group (Table 1), therefore, did not constitute a drawback for this technique.
This constitutes a major drawback in its successful application.
However, the computational complexity of the GBVS model constitutes a significant drawback for deinterlacing implementation purposes.
Furthermore the supply of steam during the heat release process, which constitutes a major drawback of the system, is quantified in order to assess the limitations of such a process.
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