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Although targeting SPOP in prostate cancer constitutes a considerable challenge, inhibiting downstream proteins escaping ubiquitination in SPOP mutant tumours may be more feasible, lending further credence to strategies targeting the P160 SRC family.
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The diagnosis of indeterminate pulmonary nodules and masses can constitute a considerable challenge in some cases.
The handling and storage of end-of-life tyres is an environmental problem and constitutes a considerable worldwide challenge.
Acute chest pain constitutes a considerable diagnostic challenge outside hospitals.
Acute chest pain still constitutes a considerable diagnostic challenge outside hospitals, especially when it comes to separating potential life-threatening illnesses (e.g. acute coronary syndrome) from less serious conditions (e.g. thoracic myalgia or dyspepsia) [ 1- 4].
Informal housing generally constitutes a considerable part of Cairo's residential districts.
In addition, the reexportation of goods constitutes a considerable portion of the country's export trade.
Frequently distinguished by considerable technical competence, wit, sophistication, and elegance, light poetry constitutes a considerable body of verse in all Western languages.
It thus constitutes a considerable sanction effect.
Still, a complete genome annotation constitutes a considerable effort and requires bioinformatic proficiency.
Hazardous alcohol use constitutes a considerable burden for the society [ 1, 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com