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Since the key researchers working in the scientific field addressed by the present study must certainly agree that the task we used clearly constituted tool use (e.g., compare the wide variety of tool use tasks reported by such researchers [3] [17]), we feel that this question over definitions is tangential to the relevance and importance of the present findings.
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Brown acknowledges that exactly what constitutes tool use is controversial.
Archerfish target jets of water at terrestrial prey, but whether this constitutes tool use has been contentious.
In that definition, we aimed to draw a line (albeit an arbitrary one) between a number of tasks that either did or did not constitute tool use.
This study describes chemically synthesized siRNAs and an endogenously synthesized shRNA, which reduce ALDH2 activity and constitute tools that should be of value for further alcohol research.
This strategy can be generally applied and these intermediate destination vectors can constitute tools of general interest.
These compounds have constituted invaluable tools in studies of the role of pathway in cancer cells, but were not sufficiently potent for animal studies.
Clinical pathways constitute a tool for quality management and specify which steps and procedures should be carried out for specific processes.
Thus, MGME Visualizer constitutes a tool of broad practical applicability.
This database constitutes a tool for pattern comparison of M. tuberculosis clinical isolates for global epidemiologic studies and phylogenetic purposes.
For all these reasons, DisGeNET constitutes a tool of choice for different types of users interested in the molecular basis of human diseases.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com