Sentence examples for constituted the rationale from inspiring English sources

The literature and the knowledge of the long-term effects of PBL on self-care after CHD have not been scrutinised or rigorously evaluated, and this constituted the rationale for designing a randomised study.

The proven synergistic activity of paclitaxel with anthracyclines (Gianni et al, 1995), and the single-agent activity of this agent as well as the demonstrated equivalent activity of PLD to doxorubicin in advanced STS, constituted the rationale for the present study performed by the Hellenic Cooperative Oncology Group.

The role of enteric flora in the pathogenesis of inflammatory bowel disease constitutes the rationale for the use of antibiotics as adjuvant agents in the treatment of ulcerative colitis (UC) and Crohn's disease.

Demonstration of HER-2 antigen overexpression in breast cancer constitutes the rationale for treatment with Trastuzumab (Baselga et al, 1998).

The present study may constitute the rationale for the design of a randomized controlled study to address the effect of such a combined organ-support strategy on mortality.

These purposes are recognized by the expert members of the parent discourse community and thereby constitute the rationale for the genre" (Swales, 1990, p. 58).

Both factors (genetic polymorphisms and intestinal microflora) can influence irinotecan intestinal toxicity: this constitutes the rationale for the necessity of evaluating also intestinal microflora and β-glucuronidase role in future studies investigating its interindividual variability.

Improving semantic interoperability by a structured representation of clinical procedures, findings and diseases constitutes the main rationale for the development of clinical terminologies and classification systems.

Those constituted the positives.

(This constituted the local option).

Supernatants constituted the nuclear fraction.