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Metal-organic frameworks (MOFs) have been emerging as important multifunctional hybrid materials offering highly diversified properties due to an extensive number of available metal ions and organic linker molecules that constitute an extensively high number of framework structures and architectures.

Quil-A, an extract of Quillaja saponaria, and its derivatives constitute the most extensively used saponins for adjuvant purposes [ 61].

Psychotropic agents, among which tricyclic antidepressants (TCAs) have been evaluated most extensively, constitute an important component in the treatment of chronic pain syndromes for >30 years.

They are constituted of a mixture of isoforms including macro and micro-variants that must be extensively characterized prior to their investigation as a drug candidate in clinical trials.

Hydro energy production constitutes the most extensively exploited renewable energy type all over the world.

These enzymes have been extensively studied and constitute one of the four superfamilies of proteolytic enzymes [ 1- 3].

The inherent nature of the treatment, and the stage of disease for which it is most extensively used, probably constitute the greatest barrier in gathering this information.

The fibroblast growth factor (FGF) receptors (FGFRs) constitute one of the most extensively studied novel therapeutic targets in the field of anticancer drug development.

The paleoecology of these plants has been extensively studied, and many constitute the focal point of ancient landscape reconstructions in museums around the world.

Polyphenols, predominantly flavonoids, such as procyanidins and anthocyanins, constitute the most important and most extensively studied group of active compounds contained in those fruits.

While miRNAs have been extensively studied [ 7– 10], lncRNAs still constitute a new, potentially fascinating, territory yet to be explored.

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