Other research suggests that organized sex parties of predominantly HIV-positive core groups, together with rectal STIs (Shigella, LGV, or rectal gonorrhoea) constitute drivers of sexual HCV transmission.
Taken together, these lines of evidence suggest that CCNE1 may not be the sole driver of this amplicon and that other genes within the 19q12 amplicon may also constitute drivers.
Further, it is unclear based upon current data as to whether the aforementioned ETNK1 mutations constitute the driver mutation for the underlying MPN or MDS/MPN.
These theories, frameworks, and approaches aim to uncover the underlying generative causal processes that constitute the drivers of policy dynamics (change and stability).
Because of their large distribution and extensive diversity, they represent a considerable source of genomic variation and as such, they constitute powerful drivers of genome evolution [1], [2].
We performed parallel RNAi screens in multiple cancer cell lines to identify genes that are essential for viability in some cell lines but not others, suggesting that these genes constitute key drivers of cellular survival in specific cancer cells.
Taken together, our results suggest that UQCRFS1, POP4, C19ORF12, CCNE1 and C19ORF2 are overexpressed in primary breast cancers and/or breast cancer cell lines harbouring their amplification, and may constitute potential drivers of this amplicon.
Indeed, perhaps one of the clearest examples of an epigenetic aberration constituting a driver event was found in the context of endometrial cancer [ 12].
Trainees and novice drivers were distinguished in two clusters, as trainees constitute the main driver cohort that is being addressed in driving skills evaluation field.
Phosphorus (P) losses from agricultural soils constitute a main driver for eutrophication of the Baltic Sea.
