"If a pack of cars is traveling slow, there's no need to constitute a sign for that".
In this case caspase activation appears to constitute a sign rather than a mechanism of cell death and the decisive event has occurred upstream or at the level of MMP, though even later activation of caspase 3 can accelerate the kinetics of apoptosis [19], [22].
HIV-1-induced syncytia are most easily discernible in histological sections of the frontal cortex, where they constitute a pathognonomic sign of HAE [16], [17].
AGAs are generally considered to be rare autoantibodies; however, Bizzaro and coworkers [ 21] suggested that the presence of AGAs in high titer in the absence of a clear clinical manifestation may constitute an early sign of systemic autoimmune diseases.
Yes, the new standard might help in the adjudication of sexual assault allegations, but its language still seems both vague — what exactly would constitute an unambiguous sign of consent?
B-lines constitute an US sign of subpleural interlobular septal thickening and are produced by repeated reflection between interfaces of tissues with a large acoustic impedance difference, such as fluid and air.
Since myoclonus usually occurs early and is usually suppressed by sedatives, status myoclonus is less frequently observed in hypothermia-treated CA survivors and cannot constitute by itself a sign of poor outcome [ 27].
However, in the modern clinical work-up of dementia, CT and MRI are cornerstones due to their ability to detect patterns of atrophy that may be specific for a neurodegenerative disease, for example medial temporal lobe atrophy constitutes an early sign of Alzheimer's disease [17, 18].
However, a discrepancy in birth weight between siblings may constitute a warning sign even in the absence of obvious pathology, and such babies may benefit from increased surveillance.
Collectively, these extra sensations or "local signs" constitute a "system of graduated, qualitative tokens" (1887 [1879]: §283) that bridge the gap between the spatial structure of the nonconscious retinal image and the spatial structure represented in conscious visual awareness.
