Sentence examples for constitute a serious challenge from inspiring English sources

If endogenous formaldehyde is available at the site of DOX action, the drug may form DOX-DNA adducts, which may constitute a serious challenge for DNA repair pathways, as they can act as interstrand cross-links [ 27, 29].

Virtually independent, sanctioned and constantly supported by the papacy, and exempt from local ecclesiastical jurisdiction, they aroused the jealousy of the clergy and constituted a serious challenge to royal authority.

If ever released in its entirety, this text will constitute a serious hermeneutical challenge.

Mosquito borne diseases constitute a serious health hazard to human.

Currently, biophysical simulations from DCM constitute a serious computational hindrance.

In real life, upskirts rightfully constitute a serious crime in this country.

These water reserves thus constitute a serious threat to the construction's stability and safety.

Spontaneous canine mammary tumors constitute a serious clinical problem.

Suicide attempts (SA) constitute a serious clinical problem.

Thus, a mutagenic effect of their repair could constitute a serious genetic burden.

Cyanobacteria constitute a serious threat to freshwater ecosystems by producing toxic secondary metabolites, e.g. microcystins.