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The phrase "constitute a serious" is correct and usable in written English.
You could use it to indicate that something is a source of risk or danger. For example, "Failure to properly maintain the equipment could constitute a serious safety hazard."
Exact(60)
He declared that this did not constitute a serious interruption and insisted on paying his opponent anyway.
A review of the law is urgently needed if such behaviour does not currently constitute a serious criminal offence.
There are currently many issues which constitute a serious threat to the health of those in detention for whom we have a duty of care.
Acts that constitute a serious violation include a deliberate advance, seizure of any point outside a party's line, and withdrawal of troops from an unfavourable or weak position.
If the troops are shifted by Pakistan, the move would constitute a serious blow to Washington's efforts to wipe out Qaeda and Taliban diehards in the rugged and lawless border region between Pakistan and Afghanistan.
"Now that's called trading with the enemy?" In an internal legal analysis last month, the publishers' association found that the regulations "constitute a serious threat to the U.S. publishing community in general and to scholarly and scientific publishers in particular".
"The facts constitute a serious fault on the side of Morgan Stanley, to the detriment of LVMH," said Gilbert Costes, the top ranking judge of the Commercial Court of Paris.
Their actions and the government's decision to mobilize the army and to classify the Maoists as terrorists constitute a serious deepening of a conflict that has claimed 2,000 lives and now affects about a third of Nepal's 75 districts.
"After reviewing all the available data, we have concluded that the new findings constitute a serious problem," Dr. Dieter Arnold, the chairman of the meeting, said in a statement.
While many questions, like asking what time you leave for work and whether you have indoor plumbing, may seem picayune, I find it hard to see how they constitute a serious breach of privacy.
Mosquito borne diseases constitute a serious health hazard to human.
More suggestions(18)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com