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The use of ultrafiltration did not constitute a protocol deviation, as some have contended [ 6, 10], and complete data on these treatments were collected.
The third-line reserve will be intravenous morphine (Morphin HCI®, Sintetica, Mendrision, Switzerland); however, its necessity will constitute a protocol violation.
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The patient was noted post-operatively to have had an abnormal bleeding duration at baseline that had not been reported in her menstrual history, constituting a protocol violation.
Even though the former constituted a protocol violation, the reasons for this occurring are not available, potentially influencing the results via significant bias or confounding.
Changes outside the pre-defined scope of an adaptive protocol, its boundaries or control mechanisms constitute a substantial protocol amendment and require RA/REC approval as specified within legislation [ 6], Figure 1.
1,3-Dipolar cycloaddition of azomethineylides to exocyclic olefins constitutes a versatile protocol for the construction of poly functionalized spiro-heterocycles viz.
The yield, speed and robust performance of the protocol constitute a substantial improvement to present manual methods, without the need of extensive equipment investments.
There are protocols for inquiry that are important for people to understand and be able to adopt, and those protocols constitute a shared lingua franca, even if the language is principally methodological.
To date there has been no attempt at determining what might constitute an adequate acupuncture protocol for the treatment of women undergoing a cycle of ART in a clinical trial.
Government airstrikes, if confirmed, would constitute a violation of a security protocol agreed to barely two weeks ago.
Taken together, these data suggest that protocol biopsies constitute a fundamental tool to improve the design of clinical trials and to define parameters that are crucial to the understanding of mechanisms leading to CAN.
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