As mentioned above, what constitutes a threatened margin has been the subject of several studies and the lower the threshold, the higher the sensitivity at the cost of specificity.
If shaves are performed, the "final" edge should be marked; i.e., nonoriented shave with even a small amount of tumor on the surface would constitute a final ink positive margin status requiring reexcision.
The results constitute a 7% false negative error margin, and for this we have two possible explanations.
However, in our opinion, a difference in persistent flare of over 20% between the usual care and dose reduction groups would constitute a clinically relevant non-inferiority margin.
A difference in persistent flare of over 20% between usual care and dose reduction would constitute a clinical relevant non-inferiority margin in our opinion.
These, then, are the mineral constituents that together with calcium carbonates produced in the oceans by biogenic activity as shells and the hard parts of plants and animals, go to make up the sedimentary packages that are deposited on and constitute a fundamental part of continental margins.
Note that while Graham discussed the margin of safety, and his reputation is in part built on this concept, he didn't give clear-cut rules for determining what constitutes an adequate margin of safety.
There is currently no consensus on what constitutes an 'adequate' margin of excision.
Despite the lack of clear published evidence of what constitutes an 'adequate' margin of excision, it is important that individual institutions adopt appropriate local protocols and evaluate their longer-term results, amending these protocols as further evidence on adequacy of surgical excision margins emerges in the literature.
For households at the margins of poverty, illnesses constitute a time when the fault lines of society become transparent, revealing the conflicts between social norms and material contingencies.
