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The phrase "constitute a breakthrough" is grammatically correct and can be used in written English.
It means to be a significant or pioneering achievement. Example: The new technology developed by the research team is expected to constitute a breakthrough in the field of renewable energy.
Exact(5)
Assemblyman Fred Thiele, a former town supervisor who has been involved in South Fork transportation issues for 25 years, agreed that the sunken road did not constitute a breakthrough.
In isolation, though, this would hardly constitute a breakthrough.
The ability to regenerate human lung tissue, if successful, would constitute a breakthrough in modern medicine.
We believe that these results contribute significantly to the progress in magnetic recording and constitute a breakthrough for materializing an unexplored areal recording density beyond 1 Tbit/in.2.
If proven effective, this would constitute a breakthrough non-operative treatment option for osteoarthritis.
Similar(55)
By the standards that prevail in Washington, that constitutes a breakthrough.
NUSSEIBEH: Earlier today Amos was saying that what constitutes a breakthrough is an emotional transformation, an event that brings people to open up their eyes to one another.
Sir Reg Empey, an Ulster Unionist minister in the government and a close ally of Mr. Trimble, said the announcement constituted a "breakthrough" but cautioned, "There is still a lot further to go".
By current Republican standards, that constitutes a breakthrough, one that negotiators of both parties could combine with measures to reduce the growth of spending — and get closer to a balanced budget.
Cooperative technology constitutes a breakthrough in the design of wireless communication systems.
The advent of anti-Tumor Necrosis Factor-α (TNFα) agents (adalimumab, etanercept, infliximab and golimumab) has constituted a breakthrough in the management of AS patients, especially in the case of persistently active forms [ 1, 10– 17].
More suggestions(14)
create a breakthrough
provide a breakthrough
constitute a success
constitute a milestone
constitute a breach
present a breakthrough
constituted a breakthrough
form a breakthrough
is a breakthrough
constitutes a breakthrough
constitute a turning point
constitute a revelation
was a breakthrough
representing a breakthrough
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com