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Will this constituency back current protests or remain loyal to the current regime?
But perhaps the president should worry more about his standing with a similar constituency back home the young Americans whose energy and votes helped bring him back to office last fall.
Now there are two ways a party can react when part of its coalition swings into the other party's orbit – by trying to win that constituency back, or by trying to expand its margins somewhere else.
The former Health Secretary, who made a point of nailing his regional colours to the mast by insisting on running his campaign from Manchester rather than Westminster, goes all misty-eyed when he recalls how he landed the Labour nomination for his Leigh constituency back in 2001.
But these are seats where the "Yes" side won a majority in September - and many are places where the SNP won the nearest equivalent Scottish Parliament constituency back in May 2011.
"American leadership involves not just playing to American constituency back home," Obama said.
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Voters in his constituency backed Brexit by 71% in the 2016 referendum.
And Puerto Ricans tend to be a swing constituency, backing Obama in 2008 and Sen. Marco Rubio, R-Fla., in 2010, meaning they could play a critical role in the state's Jan . 31primary and in the general election later.
But for Mr. Rouhani, a handshake may have proved too provocative for hard-line constituencies back home.
GOP senators like John McCain (Ariz)., Bob Corker (Tenn ., Jeff Flake (Ariz). and Ben Sasse (Neb). have certainly been willing to break with Trump publicly on certain things, but they also have pro-Trump constituencies back home to worry about.
UN agreements need to be made by consensus – ie, every party has to sign on the dotted line – and with such a vast number of countries all grandstanding to different political constituencies back home, over such a hugely complex text, the possibility of discord was always present.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com