Scientists are still working to understand the exact mechanisms by which this constellation of effects occurs.
Importantly, many bivalently marked genes are disrupted in prenatal models of alcohol exposure, which potentially may explain the constellation of effects observed in FASD.
Respiratory exposure to seawater aerosols containing brevetoxins leads to a different constellation of effects (Backer et al. 2005), some which are consistent with activation of voltage-gated sodium channels, whereas others may involve inflammatory reaction pathways (Bossart et al. 1998).
This whole constellation of immune effects associated with transfusion has been referred to as the 'TRIM' effect (transfusion-related immune modulation).
Thus, our studies indicate that inhibition of autophagy is part of the constellation of inhibitory effects of IL-10 on macrophage effector functions.
In one series, 24%% of PD patients taking dopamine agonists suffered from this potentially devastating constellation of side effects [ 82].
In summary, exposures to antiandrogens can cause adverse effects in upstream indicators, including a reduction in fetal testosterone levels or androgen receptor binding, which can increase the risk of a constellation of downstream effects including cryptorchidism, hypospadias, and, later in life, infertility.
Size, diet, ecology, locomotion, and anatomic structure provide a constellation of causes and effects that are critical factors in the evolution of the primates.
The traditional antidepressants, many of which were first introduced in the 1950's, can cause a constellation of unpleasant side effects, including dizziness, blurred vision, constipation, extreme dryness of mouth, sluggishness and a weight gain of as much as 15percentt.
VEGF pathway inhibitors produce a constellation of common side effects including fatigue, diarrhea, hypertension, and nausea.
Similarly, recent studies are starting to examine impaired cognition as one aspect of a constellation of negative psychosocial effects of HCT (37, 38).
